Perceived feasibility, facilitators and barriers to incorporating point-of-care testing for SARS-CoV-2 into emergency medical services by ambulance service staff: a survey-based approachArticle Published on 2022-11-032022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] Accuracy acquisition ambulance service Analysis approach assessments assistant Care Characteristics clinical decision clinical utility collected COVID-19 criteria current elicit Emergency emergency situation facilitator feasibility feasible Follow-up healthcare services indicated Lateral flow device majority medical service molecular diagnostics Perceived point-of-care qualitative data Qualitative research. rapid SARS-CoV-2 testing required response risk stratification SARS-CoV-2 SARS-CoV-2 test Sensitivity and specificity supported survey to define unlikely while [DOI] 10.1136/bmjopen-2022-064038 PMC 바로가기
Evaluation of qualitative and semi-quantitative cut offs for rapid diagnostic lateral flow test in relation to serology for the detection of SARS-CoV-2 antibodies: findings of a prospective studyArticle Published on 2022-10-312022-11-15 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome Analysis antibodies antibody Antibody detection assessments Blood capillary blood chemiluminescent immunoassay CLIA coronavirus coronavirus disease COVID-19 COVID-19 disease cut off cut-off Diagnosis diagnosis of COVID-19 diagnostic Efficacy ELISA evaluate facilitate gold standard identify IgM and IgG immunochromatographic assay information intensity Italy Laboratory Lateral lateral flow lateral flow immunoassay Lateral flow test measure NAAT Non-invasive nucleic acid amplification Patient patients performed POC positive Prospective Study provided Quantitative Rapid Rapid diagnostic test RDT SARS-CoV-2 SARS-CoV-2 antibody semi-quantitative sensitivity serological test serology Serology. Severity of disease specificity symptom onset Test the timing venous whole sample [DOI] 10.1186/s12879-022-07786-5 PMC 바로가기
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological EvaluationArticle Published on 2022-10-092022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Allosteric inhibitor aryl nitrile assessments binding Biological candidate carried Characteristics Compound COVID-19 COVID-19 treatments docking enzyme inhibitor Ligand M pro mechanism medium MPro protease SARS-CoV-2 Screening selected Site structure-based virtual screening. suggested target the SARS-CoV-2 Treatment Virtual screening [DOI] 10.3390/molecules27196710 PMC 바로가기
Promising natural products against SARS-CoV-2: Structure, function, and clinical trialsArticle Published on 2022-10-012022-11-15 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity acute respiratory syndrome addition analyzed antiinflammatory antivirals assessments Breakthrough infection caused clinical trial clinical trials coronavirus Coronaviruses COVID-19 Critical drug drug interaction drugs Effect effective enhancer Health immune Improvements inhibitory effect mechanism Mutation natural products. Protein RdRP Research SARS-CoV-2 shown Spread Structure structures Vaccine virus Virus Disease [DOI] 10.1002/ptr.7580 PMC 바로가기
Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID-19, in Subjects With Renal ImpairmentArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] 치료제, [키워드] 24 hour adjusted Administered adverse event adverse outcome assessments Chronic kidney disease clearance coronavirus disease COVID-19 decrease dose dose reduction Effect eliminated evaluated exhibited geometric geometric mean ratio glomerular filtration rate group increased risk kidney laboratory measurements Mild mild in severity moderate Nirmatrelvir oral participant Patient patients with moderate pharmacokinetics Phase I plasma plasma concentration positively correlated progression reducing renal renal function renal impairment risk Ritonavir severe disease severe renal impairment systemic Tolerability vital signs [DOI] 10.1002/cpt.2688 PMC 바로가기
Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemicRandomized Controlled Trial Published on 2022-09-022022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] active site activity affected applied approaches assessment assessments Canada CONSORT COVID-19 pandemic creating Critical Critical care Critical illness Cycling data entry determine discharge Endpoint enrolled extremity Guidance ICU ICUs In-hospital intensive care unit International Intervention Lower management Modification outcomes pandemic Patient Patient care physical Primary outcome Primary outcomes protocol provide Randomized Randomized controlled trial Randomized controlled trials randomized trial RCT receiving recruitment rehabilitation required Research Research design Research personnel Research report. retained risk strength Trial [DOI] 10.1186/s13063-022-06640-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessmentArticle Published on 2022-09-012022-11-16 Journal: Journal of Pharmacological and Toxicological Methods [Category] 신약개발, [키워드] Abstract Analysis Annual appear approach arising article assessments attrition automated clinical study COVID-19 drug effort FDA Giant global pandemic hERG. ICHE14/S7B in vitro in vivo manuscript Perspective Pharmacology Prevent problem protocol QT correction Regulatory Safety Safety assessment safety pharmacology Society SPS Taking Volume [DOI] 10.1016/j.vascn.2022.107206 PMC 바로가기
Improving child health through Big Data and data science Reviews Published on 2022-08-162022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] assessments Characteristics child health childhood children complex creating defined determinant developmental dimension disease risk Diseases fetal for inclusion Genetic Health highlight identify Impact IMPROVE Improving infancy Interaction mechanisms outcomes Patient pediatric phenotype Predictive provide Racial recommendation reducing Regulatory Research resource susceptibility the United State Therapies Trajectories while [DOI] 10.1038/s41390-022-02264-9 [Article Type] Reviews
Interim Recommendation of the Advisory Committee on Immunization Practices for Use of the Novavax COVID-19 Vaccine in Persons Aged ≥18 years – United States, July 202218세 이상인 사람의 Novavax COVID-19 백신 사용에 대한 예방접종 관행에 대한 자문 위원회의 임시 권고 - 미국, 2022년 7월Article Published on 2022-08-052022-09-11 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, [키워드] 95% CI Administered Adults Alpha variant assessments association authorization B.1.1.7 causal relationship cause Chain Reaction circulating Committee COVID-19 COVID-19 vaccine dose drug Efficacy efficacy analysis Emergency Emergency use authorization EUA FDA flexibility food Food and Drug Administration immunization infection with SARS-CoV-2 information Interim Matrix-M myocarditis Novavax NVX-CoV2373 per-protocol Pericarditis Person polymerase chain reaction Practice predominant PROTECT Protein provide reported reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS-CoV-2 symptomatic symptomatic COVID-19 United States vaccination Vaccine vaccine efficacy variant virus [DOI] 10.15585/mmwr.mm7131a2 PMC 바로가기 [Article Type] Article
A prospective study revealing a compounded burden of COVID-19, sex, and clinical diagnosis of alcohol use disorder and HIV infection on quality of life, anxiety, and alcohol useResearch article Published on 2022-08-012022-10-05 Journal: Journal of psychiatric research [Category] 유전자 메커니즘, 진단, [키워드] affected affecting alcohol Anxiety anxiety symptom assessments change changes in clinical Clinical diagnosis Comorbidity consequence Contact controls correlated COVID COVID-19 COVID-19 pandemic Decline declined declines Diagnosis disease spread disorder Effect Eligible participants emotional function greater group groups Health HIV HIV infection identification Infection initiated inquiry inventory life longitudinal study men mental health mitigate Pain pandemic participant people with HIV physical Prospective Study Quality Quality of life reported self-report questionnaire Sex STAI Test women [DOI] 10.1016/j.jpsychires.2022.06.017 [Article Type] Research article